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| Product Name: |
Lincomycin HCL
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| Related proudcts |
dapoxetine, d-xylose, lincomycin hcl, |
| Specifications |
GMP , EP; |
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Intramuscular administration of a single dose of 600 mg of Lincomycin produces average peak serum levels of 11.6 micrograms/ml at 60 minutes, and maintains therapeutic levels for 17 to 20 hours, for most susceptible gram-positive organisms. Urinary excretion after this dose ranges from 1.8 to 24.8 percent (mean: 17.3 percent).
A two-hour intravenous infusion of 600 mg of Lincomycin achieves average peak serum levels of 15.9 micrograms/ml and yields therapeutic levels for 14 hours for most susceptible gram-positive organisms. Urinary excretion ranges from 4.9 to 30.3 percent (mean: 13.8 percent).
The biological half-life after IM or IV administration is 5.4 ¡À 1.0 hours. The serum half-life of lincomycin may be prolonged in patients with severe i***irment of renal function, co***red to patients with normal renal function. In patients with abnormal hepatic function, serum half-life may be twofold longer than in patients with normal hepatic function. Hemodialysis and peritoneal dialysis are not effective in removing lincomycin from the serum.
Tissue level studies indicate that bile is an important route of excretion. Significant levels have been demonstrated in the majority of body tissues. Although lincomycin appears to diffuse in the cerebrospinal fluid (CSF), levels of lincomycin in the CSF appear inadequate for the treatment of meningitis.
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| Company: |
Ningbo Highmomedical Technology Co.,Ltd
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| Contact: |
Mr. Chen Haitao |
| Address: |
No.19 TianRong Street, Daxing Bio-medicine Industry Park, Zhongguancun Science Park , Beijing ,China |
| Postcode: |
315000 |
| Tel: |
86-15867886276 |
| Fax: |
86-574-87297028 |
| E-mail: |
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